Development/Plasticity/Repair Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling
نویسندگان
چکیده
Yogesh P. Wairkar,1 Hirofumi Toda,2,3 Hiroaki Mochizuki,3 Katsuo Furukubo-Tokunaga,3 Toshifumi Tomoda,2 and Aaron DiAntonio1 1Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri 63110, 2Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, and 3Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan
منابع مشابه
Unc-51 controls active zone density and protein composition by downregulating ERK signaling.
Efficient synaptic transmission requires the apposition of neurotransmitter release sites opposite clusters of postsynaptic neurotransmitter receptors. Transmitter is released at active zones, which are composed of a large complex of proteins necessary for synaptic development and function. Many active zone proteins have been identified, but little is known of the mechanisms that ensure that ea...
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